免疫系统
免疫学
先天免疫系统
获得性免疫系统
生物
干扰素
病毒
免疫
病毒学
病毒复制
细胞毒性T细胞
生物化学
体外
作者
Abdollah Jafarzadeh,Alma Naseri,Layla Shojaie,Maryam Nemati,Sara Jafarzadeh,Hossein Bannazadeh Baghi,Michael R. Hamblin,Seyed Amirreza Akhlagh,Hamed Mirzaei
标识
DOI:10.1016/j.intimp.2021.108188
摘要
The microRNA, miR-155 regulates both adaptive and innate immune responses. In viral infections, miR-155 can affect both innate immunity (interferon response, natural killer cell activity, and macrophage polarization) and adaptive immunity (including generation of anti-viral antibodies, CD8+ cytotoxic T lymphocytes, Th17, Th2, Th1, Tfh and Treg cells). In many viral infections, the proper and timely regulation of miR-155 expression is critical for the induction of an effective anti-virus immune response and viral clearance without any harmful immunopathologic consequences. MiR-155 may also exert pro-viral effects, mainly through the inhibition of the anti-viral interferon response. Thus, dysregulated expression of miR-155 can result in virus persistence and disruption of the normal response to viral infections. This review provides a thorough discussion of the role of miR-155 in immune responses and immunopathologic reactions during viral infections, and highlights its potential as a therapeutic target.
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