Linderanoids A–O, dimeric sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm

Fifteen undescribed dimeric sesquiterpenoids, linderanoids A–O along with one known lindenane-type sesquiterpenoid dimer, lindenaneolide F, were isolated and identified from the roots of Lindera aggregata. Their structures and absolute configurations were elucidated using spectroscopy and electronic circular dichroism (ECD) analysis. All the isolated compounds were screened for transforming growth factor (TGF)-β inhibitory activity, and the results showed that linderanoid E significantly inhibited the TGF- β induced smad2 phosphorylation at a concentration of 25 μM.