微熔池
肠道菌群
免疫学
生物
免疫
微生物群
粘膜免疫
免疫系统
微生物学
粘膜免疫学
派尔斑
免疫球蛋白A
免疫球蛋白G
生物信息学
作者
Sisi Lin,Subhajit Mukherjee,Juanjuan Li,Weiliang Hou,Chao Pan,Jinyao Liu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2021-05-14
卷期号:7 (20)
被引量:129
标识
DOI:10.1126/sciadv.abf0677
摘要
Methods capable of maintaining gut microbiota homeostasis to prevent bacterial translocation and infection under external threats are critical for multiple facets of human health but have been rarely reported. Here, we describe the elicitation of mucosal immunity to modulate the gut microbiota by oral delivery of living probiotics into Peyer’s patches. Probiotics are individually camouflaged within a yeast membrane, on which the embedded β-glucan can facilitate the phagocytosis of microfold cells that locate in the intestinal epithelium. The delivery of probiotics into lymphoid follicles after oral ingestion promotes robust mucosal immune responses and notably upgrades the production of secretory immunoglobulin A. The provoked immunity positively regulates the gut microflora, which, in turn, retains gut homeostasis and provides defense against environmental attacks. In two murine models of gut barrier impairment, oral administration with camouflaged probiotics effectively prevents the breakdown of intestinal barrier and evidences limited bacterial translocation and systemic inflammation.
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