抗菌剂
化学
组合化学
金属
纳米技术
细菌
水溶液中的金属离子
有机化学
生物
材料科学
遗传学
作者
Jing Liang,Dejuan Sun,Yueying Yang,Mingxue Li,Hua Li,Lixia Chen
标识
DOI:10.1016/j.ejmech.2021.113696
摘要
The antimicrobial resistance (AMR) is an intractable problem for the world. Metal ions are essential for the cell process and biological function in microorganisms. Many metal-based complexes with the potential for releasing ions are more likely to be absorbed for their higher lipid solubility. Hence, this review highlights the clinical potential of organometallic compounds for the treatment of infections caused by bacteria or fungi in recent five years. The common scaffolds, including antimicrobial peptides, N-heterocyclic carbenes, Schiff bases, photosensitive-grand-cycle skeleton structures, aliphatic amines-based ligands, and special metal-based complexes are summarized here. We also discuss their therapeutic targets and the risks that should be paid attention to in the future studies, aiming to provide information for researchers on metal-based complexes as antimicrobial agents and inspire the design and synthesis of new antimicrobial drugs.
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