Inside Cover: Red‐ and Far‐Red‐Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion (Angew. Chem. Int. Ed. 49/2021)

Insulin secretion from β-cells in intact islets can now be recorded together with calcium signal and organelles. In their Research Article on page 25846, Zhixing Chen and co-workers developed a new class of red- and far-red-emitting Zn2+ probes with minimal phototoxicity. Tailored for 4D, long-term, and multiple-color recording of Zn2+/insulin co-secretion in β-cells and islets, the new probes promise to unveil the spatial-temporal regulation of islet endocrinology.