化学
四糖
透明质酸
糖胺聚糖
产量(工程)
立体化学
多糖
生物化学
遗传学
生物
冶金
材料科学
作者
Sha Meng,Wang Yao,Xiao Zhang,Zhongjun Li
标识
DOI:10.1016/j.tetlet.2017.06.032
摘要
Hyaluronan is a glycosaminoglycan with a large number of biological activity. Hyaluronan of different molecular weight often shows different biological activity, sometimes even completely opposite, but the mechanism is not clear. Herein, the hyaluronan tetrasaccharide glycoclusters using hyaluronan tetrasaccharide obtained by enzymolysis of natural hyaluronan were firstly synthesized in high yield. The structurally determined and diverse glycoclusters were of wide molecular weight range and might be used for mimicking the biological activity of natural hyaluronan and facilitating the mechanism study.
科研通智能强力驱动
Strongly Powered by AbleSci AI