Safety Considerations in the Use of Ketorolac for Postoperative Pain

Background: Ketorolac use has significantly expanded for postoperative pain management since it first became available in the United States, primarily due to well established effects on patient pain scores and its ability to reduce perioperative opioid requirements. As an inhibitor of cyclooxygenase, ketorolac use has raised clinical concern including particular controversy regarding its potential effects on bone healing, postoperative kidney function and perioperative bleeding. Keywords: Ketorolac, postoperative pain, toradol, non-steroid anti-inflammatory drug.