小桶
下调和上调
微阵列
医学
微阵列分析技术
信号转导
信使核糖核酸
趋化因子
细胞生物学
免疫学
基因表达
生物
基因
炎症
转录组
遗传学
作者
Yue Ma,Le Shi,Cheng Zheng
标识
DOI:10.1016/j.ijporl.2017.10.046
摘要
We aimed to identify the effect of lncRNAs in CD4+ T cells on Allergic rhinitis (AR). The present study conducted a microarray to identify the expression profiles of lncRNA and mRNA in CD4+ T cells in both AR murine models and normal controls. And qRT-PCR was used to confirm the results. GO and KEGG enrichment analysis were used to show all related pathways and a co-expression network was conducted to find lncRNAs which have high correlation with these pathways. The results showed that the two groups contained a total of 158 deregulated lncRNAs, of which 110 were upregulated and 48 were downregulated. And positive regulation of calcium ion transport, B cell activation, chemokine-signaling pathways and calcium-signaling pathways may be involved in the development of T cells in AR pathology. Finally, we can find the differentially expressed mRNA in the pathways related to T cell differentiation correlated with many deregulated lncRNAs. The present study was the first to show the differential expression profiles of lncRNAs in the CD4+ T cells of an AR murine model, which may provide significant insights into AR pathogenesis and offer new treatment targets to alleviate it.
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