淋巴增殖反应
免疫系统
脾脏
细胞因子
黄曲霉毒素
肝功能
医学
免疫学
摄入
组织病理学
内科学
生物
病理
体外
外周血单个核细胞
生物化学
食品科学
作者
Angélica Tieme Ishikawa,Elisa Yoko Hirooka,P. Silva,Ana Paula Frederico Rodrigues Loureiro Bracarense,Karina Keller Marques da Costa Flaiban,Claudia Yuri Akagi,Osamu Kawamura,Márcio Costa,Eiko Nakagawa Itano
出处
期刊:Toxins
[MDPI AG]
日期:2017-11-17
卷期号:9 (11): 374-374
被引量:43
标识
DOI:10.3390/toxins9110374
摘要
Aflatoxin B₁ (AFB₁), a mycotoxin found in food and feed, exerts harmful effects on humans and animals. The liver is the earliest target of AFB₁, and its effects have been evaluated in animal models exposed to acute or chronic doses. Considering the possibility of sporadic ingestion of AFB₁-contaminated food, this study investigated the impact of a single oral dose of AFB₁ on liver function/cytokines and the lymphoproliferative response in mice. C57BL/6 mice were treated with a single oral AFB₁ dose (44, 442 or 663 μg AFB₁/kg of body weight) on the first day. Liver function (ALT, γ-GT, and total protein), cytokines (IL-4, IFN-γ, and IL-17), histopathology, and the spleen lymphoproliferative response to mitogens were evaluated on the 5th day. Although AFB₁ did not produce any significant changes in the biochemical parameters, 663 μg AFB₁/kg-induced hepatic upregulation of IL-4 and IFN-γ, along with liver tissue injury and suppression of the lymphoproliferative response to ConA (p < 0.05). In conclusion, a single oral dose of AFB₁ exposure can induce liver tissue lesions, liver cytokine modulation, and immune suppression in C57BL/6 mice.
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