阿霉素
毒性
机制(生物学)
药理学
药品
氧化应激
医学
化疗
内科学
哲学
认识论
作者
Arivalagan Pugazhendhi,Thomas Nesakumar Jebakumar Immanuel Edison,Bharath Kumar Velmurugan,Joe Antony Jacob,Indira Karuppusamy
出处
期刊:Life Sciences
[Elsevier]
日期:2018-03-11
卷期号:200: 26-30
被引量:374
标识
DOI:10.1016/j.lfs.2018.03.023
摘要
Doxorubicin (Dox) is a valuable anticancer drug for hematologic and solid tumors. Yet, it can cause multi-organ toxicities in various patients. Since toxicity evaluation is a major criterion to discuss for every experiment, the current mini-review focuses on the toxicity of Dox to multiple organs and suggests the most probable mechanism. Though several mechanisms have been suggested, the role of oxidative stress remains elusive among other mechanisms and remains the most probable mechanism for cardiotoxic effect of Dox.
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