细胞生物学
细胞粘附
祖细胞
细胞命运测定
干细胞
细胞分裂
细胞生长
细胞分化
焦点粘着
生物
细胞
信号转导
生物化学
转录因子
基因
作者
Yekaterina A. Miroshnikova,Huy Quang Le,David Schneider,Torsten Thalheim,Matthias Rübsam,Nadine Bremicker,Julien Polleux,Nadine Kamprad,Marco Tarantola,Irène Wang,Martial Balland,Carien M. Niessen,Joerg Galle,Sara A. Wickström
标识
DOI:10.1038/s41556-017-0005-z
摘要
To establish and maintain organ structure and function, tissues need to balance stem cell proliferation and differentiation rates and coordinate cell fate with position. By quantifying and modelling tissue stress and deformation in the mammalian epidermis, we find that this balance is coordinated through local mechanical forces generated by cell division and delamination. Proliferation within the basal stem/progenitor layer, which displays features of a jammed, solid-like state, leads to crowding, thereby locally distorting cell shape and stress distribution. The resulting decrease in cortical tension and increased cell-cell adhesion trigger differentiation and subsequent delamination, reinstating basal cell layer density. After delamination, cells establish a high-tension state as they increase myosin II activity and convert to E-cadherin-dominated adhesion, thereby reinforcing the boundary between basal and suprabasal layers. Our results uncover how biomechanical signalling integrates single-cell behaviours to couple proliferation, cell fate and positioning to generate a multilayered tissue.
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