N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings

抗菌剂 伤口敷料 铜绿假单胞菌 刺激 金黄色葡萄球菌 化学 保质期 伤口愈合 细菌生长 皮肤刺激 细菌 微生物学 食品科学 医学 外科 有机化学 材料科学 皮肤病科 生物 复合材料 免疫学 遗传学
作者
Buket Demir,R. M. Broughton,Mingyu Qiao,Tung‐Shi Huang,S. D. Worley
出处
期刊:Molecules [MDPI AG]
卷期号:22 (10): 1582-1582 被引量:59
标识
DOI:10.3390/molecules22101582
摘要

This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time. Moreover, the N-halamine-modified wound dressings showed superior antimicrobial efficacies when compared to commercially available silver wound dressings. Zone of inhibition tests revealed that there was no significant leaching of the oxidative chlorine from the materials, and inactivation of bacteria occurred by direct contact. Shelf life stability tests showed that the dressings were stable to loss of oxidative chlorine when they were stored for 6 months in dark environmental conditions. They also remained stable under florescent lighting for up to 2 months of storage. They could be stored in opaque packaging to improve their shelf life stabilities. In vitro skin irritation testing was performed using a three-dimensional human reconstructed tissue model (EpiDerm™). No potential skin irritation was observed. In vitro cytocompatibility was also evaluated. These results indicate that N-halamine wound dressings potentially can be employed to prevent infections, while at the same time improving the healing process by eliminating undesired bacterial growth.
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