泛素连接酶
泛素
泛素蛋白连接酶类
DNA连接酶
细胞生物学
功能(生物学)
计算生物学
生物
遗传学
化学
DNA
基因
作者
Helen Walden,Katrin Rittinger
标识
DOI:10.1038/s41594-018-0063-3
摘要
RBR ligases are an enigmatic class of E3 ubiquitin ligases that combine properties of RING and HECT-type E3s and undergo multilevel regulation through autoinhibition, post-translational modifications, multimerization and interaction with binding partners. Here, we summarize recent progress in RBR structures and function, which has uncovered commonalities in the mechanisms by which different family members transfer ubiquitin through a multistep process. However, these studies have also highlighted clear differences in the activity of different family members, suggesting that each RBR ligase has evolved specific properties to fit the biological process it regulates.
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