Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004

全国健康与营养检查调查 毒物 营养物 尿 维生素B12 化学 人口 维生素 同型半胱氨酸 甲基化 摄入 泌尿系统 生理学 内科学 医学 内分泌学 生物化学 毒性 环境卫生 有机化学 基因
作者
Margaret Kurzius-Spencer,Vanessa da Silva,Cynthia A. Thomson,Vern Hartz,Chiu Hsieh Hsu,Jefferey L. Burgess,Mary Kay O'Rourke,Robin B. Harris
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:607-608: 381-390 被引量:32
标识
DOI:10.1016/j.scitotenv.2017.07.019
摘要

Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs+MMA+DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA:DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs% and greater DMA% in adults (≥18years), with similar trends in children (6-18). In adjusted models, vitamin B6 intake (p=0.011) and RBC folate (p=0.036) were associated with lower inAs%, while dietary vitamin B12 was associated with higher inAs% (p=0.002) and lower DMA% (p=0.030). Total plasma homocysteine was associated with higher MMA% (p=0.004) and lower DMA% (p=0.003), but not with inAs%; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Oliver完成签到 ,获得积分10
刚刚
Superman完成签到 ,获得积分10
3秒前
Tina酱完成签到 ,获得积分10
3秒前
琪琪完成签到,获得积分10
3秒前
双碳小王子完成签到,获得积分10
5秒前
smottom应助科研通管家采纳,获得10
7秒前
7秒前
明时完成签到,获得积分10
8秒前
杨瑞东完成签到 ,获得积分10
11秒前
yyyy完成签到,获得积分10
19秒前
缥缈的平卉完成签到 ,获得积分10
20秒前
量子星尘发布了新的文献求助10
31秒前
李爱国应助大橙子采纳,获得10
32秒前
magictoo发布了新的文献求助30
38秒前
40秒前
yang完成签到,获得积分10
40秒前
Minicoper发布了新的文献求助10
41秒前
快乐丸子完成签到,获得积分10
42秒前
简单而复杂完成签到,获得积分10
42秒前
大橙子发布了新的文献求助10
46秒前
张牧之完成签到 ,获得积分10
48秒前
冷冷暴力完成签到,获得积分10
50秒前
YYY完成签到,获得积分10
50秒前
50秒前
gujian完成签到 ,获得积分10
53秒前
帅气的秘密完成签到 ,获得积分10
54秒前
自然函发布了新的文献求助10
58秒前
冰冰双双完成签到,获得积分10
58秒前
开心夏旋完成签到 ,获得积分0
1分钟前
我要读博士完成签到 ,获得积分10
1分钟前
活泼的大船完成签到,获得积分10
1分钟前
AFF完成签到,获得积分10
1分钟前
1分钟前
无私小小完成签到,获得积分10
1分钟前
随心所欲完成签到 ,获得积分10
1分钟前
润润轩轩完成签到 ,获得积分10
1分钟前
CodeCraft应助大橙子采纳,获得10
1分钟前
ZR完成签到,获得积分10
1分钟前
magictoo完成签到,获得积分10
1分钟前
陈昊发布了新的文献求助10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022