重组DNA
药物发现
药物开发
生产(经济)
细菌
生物
药品
生物技术
生化工程
计算生物学
生物化学
药理学
基因
工程类
遗传学
宏观经济学
经济
标识
DOI:10.1016/j.drudis.2013.11.008
摘要
The production of recombinant proteins is crucial for both the development of new protein drugs and the structural determination of drug targets. As such, recombinant protein production has a major role in drug development. Bacterial hosts are commonly used for the production of recombinant proteins, accounting for approximately 30% of current biopharmaceuticals on the market. In this review, I introduce fundamental concepts in recombinant protein production in bacteria, from drug development to production scales. Recombinant protein production processes can often fail, but how can this failure be minimised to rapidly deliver maximum yields of high-quality protein and so accelerate drug discovery?
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