四克隆
立体选择性
羟基化
四氢萘酮
化学
氧化磷酸化
区域选择性
有机化学
立体化学
组合化学
生物化学
催化作用
酶
作者
Gheorghe‐Doru Roiban,Rubén Agudo,Adriana Ilie,Richard Lonsdale,Manfred T. Reetz
摘要
Mutants of P450-BM3 evolved by directed evolution are excellent catalysts in the CH-activating oxidative hydroxylation of 1-tetralone derivatives and of indanone, with unusually high regio- and enantioselectivity being observed.
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