Transforming growth factor β‐1 as a predictor of fibrosis in tuberculous pleurisy

医学 胸膜增厚 内科学 纤维化 肺结核 胃肠病学 胸腔积液 胸膜炎 胸膜液 病理
作者
Márcia Seiscento,Francisco S. Vargas,Leila Antonângelo,Milena Marques Pagliarelli Acencio,Sidney Bombarda,Vera Luíza Capelozzi,Lisete R. Teixeira
出处
期刊:Respirology [Wiley]
卷期号:12 (5): 660-663 被引量:22
标识
DOI:10.1111/j.1440-1843.2007.01135.x
摘要

Background and objective: To clarify the influence of transforming growth factor β‐1 (TGF‐β 1 ) in the development of pleural thickening in tuberculosis (TB), the levels of TGF‐β 1 in pleural fluid and in serum of patients with pleural TB and transudative effusions were determined. Methods: TGF‐β 1 was quantified in 58 pleural fluid and serum samples of patients with TB ( n = 50) or transudative effusions ( n = 8). Pleural thickening evaluated by high‐resolution CT was scored as 0 (<3 mm); 1 (≥3 and <10 mm) or 2 (≥10 mm). Results: The highest pleural fluid TGF‐β 1 levels before treatment for TB were observed in patients with a pleural thickness score of 2. Of the 14 patients with score 1, five regressed to 0, five progressed to 2, and four maintained 1. All 17 patients with score 2 maintained this evaluation. Patients who presented score 1 and progressed to 2 had higher TGF‐β 1 levels than those who maintained the same score or regressed (score 1 or 0). Patients with score 2 (before or after treatment) had higher TGF‐β 1 levels than those with score 0 or 1. Conclusion: Pleural fluid and serum TGF‐β 1 levels were higher in patients with TB, with a correlation between pleural fluid TGF‐β 1 levels before treatment and the degree of pleural thickening. This finding suggests that TGF‐β 1 might be considered as a predictor of pleural thickening in pleural tuberculosis.
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