生物
肾细胞癌
生物标志物
细胞
基因表达
运输机
流出
信使核糖核酸
锌
癌症
基因
癌症研究
内科学
遗传学
医学
化学
有机化学
作者
Devendra Pal,Ujjawal Sharma,Shrawan Kumar Singh,Rajendra Prasad
出处
期刊:Gene
[Elsevier]
日期:2014-11-01
卷期号:552 (1): 195-198
被引量:23
标识
DOI:10.1016/j.gene.2014.09.010
摘要
Zinc is an indispensable trace element which is vital for the functioning of numerous cellular processes like cell replication and growth. Cellular zinc homeostasis is tightly regulated by zinc transporters involved in zinc influx and efflux processes. Notwithstanding, the association of zinc transporters with the aggressiveness of cancer, especially renal cell carcinoma (RCC), is unknown. In view of the fact, the present study was initiated to ascertain whether ZIP10 transporter expression is modulated during RCC progression. A total of 57 samples of RCC and corresponding normal renal tissue were analyzed for ZIP10 gene expression by real time PCR. We observed significantly higher expression of ZIP10 mRNA (P=0.002) in high grade clear cell RCC tissue (Grades III & IV) as compared to low grade clear cell RCC tissue (Grades I & II). A significant difference was also observed in the ZIP10 expression in different types of RCC (P=0.001). This is the first study which shows a significant correlation between ZIP10 mRNA expressions with aggressiveness of RCC. Therefore, ZIP10 mRNA expression could be used as a possible biomarker for the aggressive behavior of RCC and a promising target of novel treatment strategies.
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