Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin

清洁剂 痤疮 敏感皮肤 皮肤干燥 洗剂 皮肤病科 皮肤护理 医学 角质层 保湿霜 头皮 药理学 化学 食品科学 病理 护理部
作者
Kenichi Isoda,Tsuyoshi Seki,Yosuke Inoue,Koji Umeda,Takahiro Nishizaka,Hisateru Tanabe,Yutaka Takagi,Koichi Ishida,Hitoshi Mizutani
出处
期刊:Journal of Dermatology [Wiley]
卷期号:42 (2): 181-188 被引量:42
标识
DOI:10.1111/1346-8138.12720
摘要

Abstract Acne is a common skin disease that involves the seborrheic area of the face and results from the obstruction of hair follicles followed by inflammation. Careful face washing helps to improve and prevent acne; however, intensive washing has a risk of inducing skin barrier impairment and dry skin, especially in sensitive skin. We hypothesized that skin care combining mild skin cleansing and intensive moisturizing (“combination skin care”) may be effective in the care of acne in subjects with dry skin and/or sensitive skin. We developed a combination skin care with a weakly acidic foaming facial skin cleanser based on a mild detergent, an aqueous lotion with eucalyptus extract and a moisturizing gel containing pseudo‐ceramide and eucalyptus extract. To optimize an ideal facial skin care system for mild acne on sensitive skin, we performed a 4‐week clinical trial with 29 post‐adolescent Japanese women with mild acne with dry and sensitive skin. The acne significantly decreased after this trial accompanied by the improvement of dry skin, a significantly increased endogenous ceramide level in the stratum corneum and an elongated alkyl chain length of the non‐hydroxy acyl sphingosine type ceramide. No adverse events due to the test samples were observed. Based on diagnosis by a dermatologist, 97% of the subjects found the combination skin care to be “useful” or “slightly useful”. Based on these findings, the combined use of a facial skin cleanser and moisturizers is safe and effective for the care of acne in post‐adolescent Japanese women with sensitive skin.
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