姜黄素
A549电池
细胞凋亡
细胞生长
细胞
细胞色素c
化学
Bcl-2相关X蛋白
细胞生物学
癌细胞
癌症研究
生物
分子生物学
程序性细胞死亡
癌症
生物化学
半胱氨酸蛋白酶3
遗传学
作者
Yue Li,Shuai Zhang,Jianxiong Geng,Xiaoyang Serene Hu
标识
DOI:10.7314/apjcp.2013.14.8.4599
摘要
We intended to study the mechanism of the inhibitory action of curcumin on human non-small cell lung cancer A549 cell. The cell growth was determined by CCK-8 assay, and the results indicated that curcumin inhibited the cell proliferation in a concentration dependent manner. And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2. We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells. In addition, curcumin affect the mitochondrial apoptosis pathway. These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.
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