优势比
医学
置信区间
腰围
体质指数
逻辑回归
混淆
增生
全国健康与营养检查调查
人口
内科学
良性前列腺增生(BPH)
前列腺
生理学
妇科
环境卫生
癌症
作者
Amit Gupta,Arnold Schecter,Corinne Aragaki,Claus G. Roehrborn
标识
DOI:10.1097/01.jom.0000205417.12621.17
摘要
Dioxins decrease prostate weight, reduce androgen responsiveness, and inhibit prostate morphogenesis in rats. We assessed the association of dioxins and benign prostatic hyperplasia (BPH) in participants in the National Health and Nutritional Examination Survey 1999-2000.Forty-two participants were classified as having BPH and 99 were classified as controls. Dioxin exposure was expressed as dioxin toxic equivalents (TEQ). Age, body mass index, waist circumference, race/ethnicity, smoking, physical activity, and education were assessed as potential confounders.After age adjustment, men without BPH had 20.9% higher TEQs (95% confidence interval [CI] = 5.4-38.7%) as compared with men with BPH. On weighted, multivariate, logistic regression analyses, men with higher dioxin levels had lower odds of having BPH (odds ratio = 0.22, 95% CI = 0.08-0.62).Dioxin exposure in the general population may be associated with decreased odds of BPH. Our study findings need to be confirmed.
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