Investigation of keratinocyte regulation of collagen I synthesis by dermal fibroblasts in a simplein vitromodel

Background Hypertrophic scarring and skin graft contracture are major causes of morbidity after burn injuries. A prominent feature is excessive fibroplasia with accumulation of increased fibrillar collagen relative to normal scar tissue. The application of split‐thickness skin grafts or cultured epithelial autografts to burn wounds is known to reduce scarring and contraction.