STAT蛋白
MAPK/ERK通路
信号转导
生物
免疫学
贾纳斯激酶
细胞生物学
嗜酸性粒细胞增多症
细胞因子
激酶
癌症研究
车站3
作者
Hiromasa Inoue,Reiko Kato,Satoru Fukuyama,Atsushi Nonami,Kouji Taniguchi,Koichiro Matsumoto,Takako Nakano,Miyuki Tsuda,Manabu Matsumura,Masato Kubo,Fumihiko Ishikawa,Byoung Gon Moon,Kiyoshi Takatsu,Yoichi Nakanishi,Akihiko Yoshimura
摘要
T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the Janus kinase/signal transducer and activator of transcription (STAT) and the Ras-extracellular signal-regulated kinase (ERK) signaling pathways. Although the suppressor of cytokine signaling (SOCS) family proteins have been shown to regulate the STAT pathway, the mechanism regulating the ERK pathway has not been clarified. The Sprouty-related Ena/VASP homology 1-domain-containing protein (Spred)-1 has recently been identified as a negative regulator of growth factor-mediated, Ras-dependent ERK activation. Here, using Spred-1-deficient mice, we demonstrated that Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness, without affecting helper T cell differentiation. Biochemical assays indicate that Spred-1 suppresses IL-5-dependent cell proliferation and ERK activation. These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma.
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