Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy

ChemMedChemVolume 3, Issue 3 p. 425-428 Communication Cell Specific Aptamer–Photosensitizer Conjugates as a Molecular Tool in Photodynamic Therapy Prabodhika Mallikaratchy, Prabodhika Mallikaratchy Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this authorZhiwen Tang, Zhiwen Tang Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this authorWeihong Tan, Weihong Tan [email protected] Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this author Prabodhika Mallikaratchy, Prabodhika Mallikaratchy Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this authorZhiwen Tang, Zhiwen Tang Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this authorWeihong Tan, Weihong Tan [email protected] Department of Chemistry, University of Florida, Center for Research at Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA, Fax: (+1) 352-846-2410Search for more papers by this author First published: 07 March 2008 https://doi.org/10.1002/cmdc.200700260Citations: 60Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Photodynamic therapy for tumors. This paper describes the application of a molecular construct of a photosensitizer and an aptamer for phototherapeutically targeting tumor cells. Coupled with the advantages of the cell-SELEX in generating multiple effective aptamers for diseased cell recognition, we will be able to develop highly efficient photosensitizer-based therapeutic reagents for clinical applications. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2008/z700260_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume3, Issue3Special Issue: Medicinal Chemistry in ParasitologyMarch 14, 2008Pages 425-428 RelatedInformation