亚精胺
多胺
精胺
寿命
细胞生长
生物
腐胺
细胞
生物化学
细胞生物学
酶
进化生物学
作者
Nadège Minois,Didac Carmona-Gutiérrez,Frank Madeo
出处
期刊:Aging
[Impact Journals LLC]
日期:2011-08-21
卷期号:3 (8): 716-732
被引量:373
标识
DOI:10.18632/aging.100361
摘要
Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms. Polyamines have also been involved in stress resistance. On the other hand, polyamines are increased in cancer cells and are a target for potential chemotherapeutic agents. In this review, we bring together these various results and draw a picture of the state of our knowledge on the roles of polyamines in aging, stress and diseases.
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