Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment

神经发生 双皮质醇 海马结构 社会失败 抗抑郁药 齿状回 皮质酮 心理学 神经科学 人口 萧条(经济学) 海马体 内分泌学 内科学 精神科 医学 激素 经济 宏观经济学 环境卫生
作者
Pieter van Bokhoven,Charlotte A. Oomen,Witte J.G. Hoogendijk,August B. Smit,Paul J. Lucassen,Sabine Spijker
出处
期刊:European Journal of Neuroscience [Wiley]
卷期号:33 (10): 1833-1840 被引量:125
标识
DOI:10.1111/j.1460-9568.2011.07668.x
摘要

Major depressive disorder is a chronic disabling disease, often triggered and exacerbated by stressors of a social nature. Hippocampal volume reductions have been reported in depressed patients. In support of the neurogenesis theory of depression, in several stress-based animal models of depression, adult hippocampal neurogenesis was reduced and subsequently rescued by parallel antidepressant treatment. Here, we investigated whether repeated social defeat and subsequent individual housing for 3 months induces long-lasting changes in adult hippocampal neurogenesis in rats, and whether these can be normalized by late antidepressant treatment, as would match human depression. Neurogenesis was analysed by stereological quantification of the number of immature doublecortin (DCX)-immunopositive cells, in particular young (class I) and more mature (class II) DCX+ cells, to distinguish differential effects of stress or drug treatment on these subpopulations. Using this social defeat paradigm, the total DCX+ cell number was significantly reduced. This was most profound for older (class II) DCX+ cells with long apical dendrites, whereas younger, class I cells remained unaffected. Treatment with the broad-acting tricyclic antidepressant imipramine, only during the last 3 weeks of the 3-month period after social defeat, completely restored the reduction in neurogenesis by increasing both class I and II DCX+ cell populations. We conclude that despite the lack of elevated corticosterone plasma levels, neurogenesis is affected in a lasting manner by a decline in a distinct neuronal population of more mature newborn cells. Thus, the neurogenic deficit induced by this social defeat paradigm is long-lasting, but can still be normalized by late imipramine treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
bkagyin应助大钊采纳,获得10
2秒前
李健的粉丝团团长应助XYJ采纳,获得10
2秒前
3秒前
桔梗发布了新的文献求助10
3秒前
albertxin发布了新的文献求助10
4秒前
wangchong完成签到 ,获得积分10
4秒前
Huang2547发布了新的文献求助10
4秒前
wanci应助Mr.K采纳,获得10
5秒前
阳大哥发布了新的文献求助30
5秒前
5秒前
12完成签到,获得积分10
6秒前
Ava应助暗栀采纳,获得10
6秒前
6秒前
海城好人完成签到,获得积分10
6秒前
ED给ED的求助进行了留言
7秒前
7秒前
Kumquat完成签到,获得积分10
7秒前
乖猫要努力应助小学渣采纳,获得10
7秒前
Owen应助Kenny采纳,获得10
7秒前
观莲客发布了新的文献求助10
7秒前
情怀应助木有采纳,获得10
7秒前
所所应助怕黑的银耳汤采纳,获得10
7秒前
8秒前
Camellia完成签到,获得积分10
8秒前
Wang发布了新的文献求助10
8秒前
zaza完成签到 ,获得积分10
8秒前
9秒前
9秒前
honghuxian发布了新的文献求助10
11秒前
CipherSage应助苗条的小肥羊采纳,获得10
11秒前
chenhunhun完成签到,获得积分10
11秒前
吴子鹏完成签到,获得积分10
12秒前
12秒前
安详的琳发布了新的文献求助10
12秒前
科研通AI2S应助菜菜果冻采纳,获得10
13秒前
tongke完成签到,获得积分10
13秒前
DJ发布了新的文献求助10
13秒前
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971277
求助须知:如何正确求助?哪些是违规求助? 3516009
关于积分的说明 11180382
捐赠科研通 3251075
什么是DOI,文献DOI怎么找? 1795664
邀请新用户注册赠送积分活动 875988
科研通“疑难数据库(出版商)”最低求助积分说明 805209