蛋白质酪氨酸磷酸酶
免疫系统
磷酸酶
生物
细胞生物学
蛋白质磷酸化
激酶
酪氨酸磷酸化
基因
磷酸化
酪氨酸
生物化学
蛋白激酶A
遗传学
作者
Tomas Mustelin,Torkel Vang,Nunzio Bottini
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2005-01-01
卷期号:5 (1): 43-57
被引量:348
摘要
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases. Together, cells of the immune system express at least half of the 107 protein tyrosine phosphatase (PTP) genes in the human genome, most of which encode multidomain proteins that contain protein- and phospholipid-interaction domains. Here, we discuss the diverse but specific, and important, roles that PTPs have in immune cells, focusing mainly on T and B cells, and we highlight recent evidence that even subtle alterations in PTPs can cause immune dysfunction and human disease.
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