化学
PEG比率
高分子化学
乙二醇
共聚物
生物结合
差示扫描量热法
分散性
聚合
质子核磁共振
有机化学
组合化学
聚合物
热力学
物理
经济
财务
作者
Boris Obermeier,Holger Frey
摘要
A series of random copolymers comprising ethylene oxide (EO) and 0−100% allyl glycidyl ether (AGE) has been prepared by anionic ring-opening polymerization with molecular weights between 5000 and 13 600 g/mol and polydispersity indices in the range of 1.04−1.19. As key for the homogeneity of the PEG conjugates, real-time 1H NMR polymerization kinetics, 13C NMR analysis of triad sequence distribution, and analysis of the thermal behavior by differential scanning calorimetry (DSC) revealed a distinctive random copolymer structure. Via thiol−ene coupling (TEC), showing mainly "click" characteristics and nearly quantitative yields, PEG derivatives with multiple amino, carboxy, or hydroxy functionalities have been prepared, providing suitable reactivities for further attachment. Without further modification, P(EO-co-AGE)s were conjugated with cysteine or the tripeptide glutathione (GSH) via TEC, resulting in well-defined hybrid materials with multiple peptide units conjugated to the PEG backbone. The results demonstrate superior loading capacity of the copolymers in comparison to the PEG homopolymer.
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