TRPC公司
瞬时受体电位通道
TRPC5公司
TRPC1型
细胞生物学
离子通道
伸展激活离子通道
化学
功能(生物学)
磷脂酶C
生物
生物物理学
受体
机械敏感通道
生物化学
信号转导
作者
Guillermo Vázquez,Barbara J. Wedel,Omar Aziz,Mohamed Trebak,James W. Putney
标识
DOI:10.1016/j.bbamcr.2004.08.015
摘要
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptor activation mechanism in Drosophila. The seven mammalian TRPCs constitute a family of channels which have been proposed to function as store-operated as well as second messenger-operated channels in a variety of cell types. TRPC channels, together with other more distantly related channel families, make up the larger TRP channel superfamily. This review summarizes recent findings on the structure, regulation and function of the apparently ubiquitous TRPC cation channels.
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