二烯丙基二硫化物
中国仓鼠卵巢细胞
遗传毒性
化学
细胞毒性
姐妹染色单体交换
细胞毒性T细胞
微克
仓鼠
中国仓鼠
生物化学
分子生物学
体外
生物
毒性
细胞凋亡
有机化学
受体
作者
S. R. R. Musk,Paul R. Clapham,Ian T. Johnson
标识
DOI:10.1016/s0278-6915(97)00120-8
摘要
Two compounds found in garlic, diallyl sulfide (DAS) and diallyl disulfide (DDS), were tested for cytotoxic and genotoxic effects in a Chinese hamster ovary cell line. DDS was found to be more cytotoxic than DAS (showing a Dq of 1.6 micrograms/ml and a D0 of 0.6 microgram/ml as opposed to values of 295 and 90 micrograms/ml, respectively). Both compounds were found to induce both chromosome aberrations and sister chromatid exchanges (SCEs) with DDS again being more active on a weight-for-weight basis, exhibiting activity at concentrations below 10 micrograms/ml compared with the levels of 300 micrograms/ml and above required for DAS to show any effect. The addition of rat liver S-9 activation fraction to the assays modified the effects of the two compounds in a non-consistent manner. It reduced the induction of SCEs by both compounds, enhanced the generation of aberrations by DDS (but not by DAS) and radically altered the parameters of both survival curves, reducing the Dq values almost to zero but increasing the D0 values.
科研通智能强力驱动
Strongly Powered by AbleSci AI