Relative Activities of Organosulfur Compounds Derived From Onions and Garlic in Increasing Tissue Activities of Quinone Reductase and Glutathione Transferase in Rat Tissues

二烯丙基二硫化物 二烯丙基三硫化物 有机硫化合物 化学 谷胱甘肽 还原酶 生物化学 谷胱甘肽还原酶 硫化物 硫黄 有机化学 谷胱甘肽过氧化物酶 细胞凋亡
作者
Rex Munday,Christine M. Munday
出处
期刊:Nutrition and Cancer [Informa]
卷期号:40 (2): 205-210 被引量:91
标识
DOI:10.1207/s15327914nc402_18
摘要

There is evidence that onions and garlic protect against cancer in humans. It has been suggested that this effect is due to the organosulfur compounds in these vegetables and that these substances act through induction of phase II detoxification enzymes. In the present studies, we have compared the ability of diallyl sulfide, dially disulfide, and diallyl trisulfide, compounds that are derived from garlic, to increase the activity of the phase II enzymes quinone reductase and glutathione transferase in a variety of rat tissues. We have also examined the onion-derived substances, dipropyl sulfide, dipropyl disulfide, dipropenyl sulfide, and dipropenyl disulfide, under identical conditions. Diallyl trisulfide and diallyl disulfide were potent inducers of the phase II enzymes. Dipropenyl disulfide was much less active, while little effect on enzyme activity was seen in animals dosed with dipropyl disulfide. Diallyl sulfide and dipropyl sulfide were weak inducers of quinone reductase and glutathione transferase, but dipropenyl sulfide was very active, with an effect similar to that of diallyl disulfide. It is possible that diallyl disulfide and diallyl trisulfide are important in the anticancer action of garlic, while dipropenyl sulfide could be involved in the beneficial action of onions.
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