Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial

医学 危险系数 胶质瘤 随机对照试验 放射治疗 剂量分馏 总体生存率 放射科 核医学 内科学 置信区间 癌症研究
作者
Mohamed S. Zaghloul,Eman Eldebawy,Soha Ahmed,Amr Mousa,Amr Amin,Amal Refaat,Iman Zaky,N. Elkhateeb,M. Sabry
出处
期刊:Radiotherapy and Oncology [Elsevier BV]
卷期号:111 (1): 35-40 被引量:89
标识
DOI:10.1016/j.radonc.2014.01.013
摘要

Background The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts. Purpose To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy. Patients and methods Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39 Gy/13 fractions in 2.6 weeks) and conventional (CF) arm (54 Gy/30 fractions in 6 weeks). Results The median and one-year overall survival (OS) was 7.8 months and 36.4 ± 8.2% for the hypofractionated arm, and 9.5 and 26.2 ± 7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70–1.89) (p = 0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6 months and 22.5 ± 7.1%, compared to 7.3 and 17.9 ± 7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67–1.90) (p = 0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms. Conclusions Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
栗子的小母牛完成签到,获得积分10
刚刚
dh完成签到,获得积分10
3秒前
岩墩墩完成签到,获得积分10
4秒前
克姑美完成签到 ,获得积分10
7秒前
pangao完成签到,获得积分10
7秒前
ysssbq完成签到,获得积分10
9秒前
10秒前
上好佳完成签到 ,获得积分10
10秒前
大模型应助Yeong采纳,获得10
11秒前
量子星尘发布了新的文献求助30
11秒前
12秒前
123完成签到,获得积分10
12秒前
谢陈完成签到 ,获得积分10
13秒前
lilili完成签到,获得积分10
14秒前
15秒前
xiaoying发布了新的文献求助10
15秒前
SciGPT应助Eric_Liuzy采纳,获得10
16秒前
liu完成签到 ,获得积分10
16秒前
qixiaoqi发布了新的文献求助10
17秒前
18秒前
A溶大美噶发布了新的文献求助10
18秒前
19秒前
19秒前
20秒前
21秒前
22秒前
kevin发布了新的文献求助10
22秒前
满意的初南完成签到 ,获得积分10
23秒前
橙橙橙发布了新的文献求助10
23秒前
万能图书馆应助EVEN采纳,获得10
23秒前
23秒前
Yeong发布了新的文献求助10
24秒前
范先生发布了新的文献求助10
25秒前
disciple完成签到,获得积分10
26秒前
沉默凌寒完成签到,获得积分10
26秒前
cc完成签到,获得积分10
26秒前
27秒前
糖豆完成签到,获得积分10
27秒前
smottom完成签到,获得积分0
28秒前
贰鸟完成签到,获得积分0
28秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048