A Convenient Synthesis of 5-Hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane and Itsβ-Methoxyethoxymethyl Derivative

Abstract 5-(β-methoxyethoxymethyl)-1-aza-3,7-dioxabicyclo[3.3.0]-octane (1) was prepared in high yield by a reaction of tris-(hydroxymethyl)-aminomethane (TRIS) with β-methoxyethoxymethylchloride (MEMCl).