泛素
脱氮酶
过程性
泛素结合酶
泛素连接酶
酶
细胞生物学
链条(单位)
泛素蛋白连接酶类
生物化学
泛素类
延伸率
生物
化学
材料科学
基因
物理
极限抗拉强度
冶金
聚合酶
天文
作者
Yihong Ye,Michael Rapé
摘要
Ubiquitin-conjugating enzymes (E2s) are major regulators of ubiquitin chain assembly. These enzymes control ubiquitin chain initiation or elongation, the processivity of chain formation and the topology of the assembled chains. The modification of proteins with ubiquitin chains can change their localization, activity and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s), it is the E2s that have recently emerged as key mediators of chain assembly. These enzymes are able to govern the switch from ubiquitin chain initiation to elongation, regulate the processivity of chain formation and establish the topology of assembled chains, thereby determining the consequences of ubiquitylation for the modified proteins.
科研通智能强力驱动
Strongly Powered by AbleSci AI