二苯甲酮
化学
芳构化
试剂
杂原子
乙烯
亚甲基
吡咯
自由基取代
药物化学
组合化学
光化学
立体化学
有机化学
激进的
烷基
催化作用
作者
Yuuki Amaoka,Masanori Nagatomo,Mizuki Watanabe,Keyu Tao,Shunsuke Kamijo,Masayuki Inoue
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2014-06-30
卷期号:5 (11): 4339-4345
被引量:107
摘要
The direct alkenylation of C(sp3)–H bonds was achieved by employing benzophenone and 1,2-bis(phenylsulfonyl)ethylene under photo-irradiation conditions. This simple metal-free reaction enables the substitution of heteroatom-substituted methine, methylene and aliphatic C(sp3)–H bonds by (E)-sulfonylalkene units in a highly chemoselective manner. The derived sulfonylalkenes were further converted in a single step to the prenyl derivatives via a second photo-induced radical substitution and to the pyrrole derivatives via cyclization and aromatization steps. The present protocol thus serves as an efficient method for the direct extension of carbon skeletons for the synthesis of structurally complex natural products and pharmaceuticals.
科研通智能强力驱动
Strongly Powered by AbleSci AI