化学
单加氧酶
恶臭假单胞菌
环戊酮
生物转化
酮
立体化学
内酯
生物转化
对映体
樟脑
生物催化
有机化学
酶
发酵
催化作用
细胞色素P450
反应机理
作者
B. M. Adger,M. Teresa Bes,Gideon Grogan,Raymond McCague,S. Pedragosa‐Moreau,Stanley M. Roberts,Raffaella Villa,Peter Wan,Andrew J. Willets
标识
DOI:10.1016/s0968-0896(96)00234-9
摘要
2-(2-Acetoxyethyl)cyclohexanone (4) was converted into the lactone (−)-(5) regio- and enantioselectively using 2-oxo-Δ3-4,5,5-trimethylcyclopentenyl acetyl-CoA monooxygenase, an NADPH-dependent Baeyer-Villiger monooxygenase from camphor grown Pseudomonas putida NCIMB 10007. The lactone (−)-(5) was converted into (R)-(+)-lipoic acid in six steps. In contrast cyclopentanone monooxygenase, an NADPH-dependent Baeyer-Villiger monooxygenase from cyclopentanol-grown Pseudomonas sp. NCIMB 9872 selectively oxidized the (S)-enantiomer of the ketone (4) giving better access to optically enriched, naturally occurring lipoic acid.
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