Role of calcium ions in regulation of mammalian intramitochondrial metabolism

articleRole of calcium ions in regulation of mammalian intramitochondrial metabolismJ. G. McCormack, A. P. Halestrap, and R. M. DentonJ. G. McCormackDepartment of Biochemistry, University of Leeds, United Kingdom., A. P. HalestrapDepartment of Biochemistry, University of Leeds, United Kingdom., and R. M. DentonDepartment of Biochemistry, University of Leeds, United Kingdom.Published Online:01 Apr 1990https://doi.org/10.1152/physrev.1990.70.2.391MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByDeterminants, maintenance, and function of organellar pHSpencer A. Freeman, Sergio Grinstein, and John Orlowski14 October 2022 | Physiological Reviews, Vol. 103, No. 1Energy metabolism design of the striated muscle cellBrian Glancy and Robert S. 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Reinert, Robert L. Dunbar, Wangcai Gao, Gang Chen, and Timothy J. Ebner1 July 2004 | Journal of Neurophysiology, Vol. 92, No. 1Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycleBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1658, No. 1-2Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neuronsCell Calcium, Vol. 36, No. 1Effects of Secretagogues and Bile Acids on Mitochondrial Membrane Potential of Pancreatic Acinar Cells14 April 2004 | Journal of Biological Chemistry, Vol. 279, No. 26Calcium and mitochondria12 April 2004 | FEBS Letters, Vol. 567, No. 1Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?4 May 2004 | FEBS Letters, Vol. 567, No. 1Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling PathwaysANDRÁS SPÄT, and LÁSZLÓ HUNYADY1 April 2004 | Physiological Reviews, Vol. 84, No. 2Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondriaArchives of Biochemistry and Biophysics, Vol. 424, No. 1The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseasesBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1655NADH Oxidase Activity of Rat Cardiac Sarcoplasmic Reticulum Regulates Calcium-Induced Calcium ReleaseCirculation Research, Vol. 94, No. 4Effects of polyamines on mitochondrial Ca2+ transportBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1661, No. 2Glomerulosa cell—a unique sensor of extracellular K+ concentrationMolecular and Cellular Endocrinology, Vol. 217, No. 1-2Modulation of [Ca2+] Signaling Dynamics and Metabolism by Perinuclear Mitochondria in Mouse Parotid Acinar CellsJournal of Biological Chemistry, Vol. 279, No. 13Respiration-dependent Removal of Exogenous H 2 O 2 in Brain Mitochondria20 November 2003 | Journal of Biological Chemistry, Vol. 279, No. 6Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cellsElena N. Dedkova, Xiang Ji, Stephen L. Lipsius, and Lothar A. 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Marchant, Viviana Ramos, and Ian Parker1 June 2002 | American Journal of Physiology-Cell Physiology, Vol. 282, No. 6NMDA-Induced Calcium Loads Recycle Across the Mitochondrial Inner Membrane of Hippocampal Neurons in CultureGuang Jian Wang, and Stanley A. Thayer1 February 2002 | Journal of Neurophysiology, Vol. 87, No. 2NEURONAL POPULATIONS OF RAT CEREBRAL CORTEX AND HIPPOCAMPUS EXPRESSED A HIGHER DENSITY OF L-TYPE Ca 2+ CHANNEL THAN CORRESPONDING CEREBRAL VESSELS10 August 2002 | Clinical and Experimental Hypertension, Vol. 24, No. 7-8Mitochondrial function in normal and diabetic β-cells13 December 2001 | Nature, Vol. 414, No. 6865Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstateKoichi Ochiai, Jianyi Zhang, Guangrong Gong, Yi Zhang, Jingbo Liu, Yun Ye, Xiaoyun Wu, Haiying Liu, Yo Murakami, Robert J. Bache, Kamil Ugurbil, and Arthur H. L. From1 October 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 281, No. 4Stimulus-Secretion Coupling and Mitochondrial Metabolism in Steroid-Secreting CellsAndrás Spät, János G. Pitter, Tibor Rohács, and György Szabadkai1 October 2001 | Physiology, Vol. 16, No. 5Signaling Takes a Breath – New Quantitative Perspectives on Bioenergetics and Signal TransductionImmunity, Vol. 15, No. 4Calcium-mediated activation of pyruvate dehydrogenase in severely injured postischemic myocardiumJerome Terrand, Irene Papageorgiou, Nathalie Rosenblatt-Velin, and Rene Lerch1 August 2001 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 281, No. 2Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsyBrain Research, Vol. 903, No. 1-2A SUBPOPULATION OF MITOCHONDRIA PREVENTS CYTOSOLIC CALCIUM OVERLOAD IN ENDOTHELIAL CELLS AFTER COLD ISCHEMIA/REPERFUSIONTransplantation, Vol. 71, No. 12Oscillations and hypoxic changes of mitochondrial variables in neurons of the brainstem respiratory centre of mice1 May 2001 | The Journal of Physiology, Vol. 533, No. 1Chapter 10 Calcium flux measurements in apoptosisMitochondrial oxidative stress and metabolic alterations in neurodegenerative disordersMitochondrial Ca 2+ -induced Ca 2+ Release Mediated by the Ca 2+ UniporterMolecular Biology of the Cell, Vol. 12, No. 1Pathophysiological and protective roles of mitochondrial ion channels1 November 2000 | The Journal of Physiology, Vol. 529, No. 1Mitochondria as all-round players of the calcium game12 August 2004 | The Journal of Physiology, Vol. 529, No. 1Mitochondria and calcium: from cell signalling to cell death12 August 2004 | The Journal of Physiology, Vol. 529, No. 1The machinery of local Ca 2+ signalling between sarco‐endoplasmic reticulum and mitochondria1 November 2000 | The Journal of Physiology, Vol. 529, No. 1Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria1 June 2000 | The Journal of Physiology, Vol. 525, No. 2Ca2+- and Metabolism-Related Changes of Mitochondrial Potential in Voltage-Clamped CA1 Pyramidal Neurons In SituS. Schuchmann, M. Lückermann, A. Kulik, U. Heinemann, and K. Ballanyi1 March 2000 | Journal of Neurophysiology, Vol. 83, No. 3Ca2+ activation of heart mitochondrial oxidative phosphorylation: role of the F0/F1-ATPasePaul R. Territo, Vamsi K. Mootha, Stephanie A. French, and Robert S. Balaban1 February 2000 | American Journal of Physiology-Cell Physiology, Vol. 278, No. 2Mitochondrial Ca 2+ homeostasis during Ca 2+ influx and Ca 2+ release in gastric myocytes from Bufo marinus1 February 2000 | The Journal of Physiology, Vol. 522, No. 3Mitochondria and Neuronal SurvivalDavid G. Nicholls, and Samantha L. Budd1 January 2000 | Physiological Reviews, Vol. 80, No. 1Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic heartsJ. Michael O’Donnell, Lawrence T. White, and E. Douglas Lewandowski1 September 1999 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 277, No. 3Analysis of the Mechanisms of Mitochondrial NADH Regulation in Cardiac TrabeculaeBiophysical Journal, Vol. 77, No. 3A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency1 August 1999 | Nature Medicine, Vol. 5, No. 8Oxygen delivery does not limit cardiac performance during high work statesJianyi Zhang, Yo Murakami, Yi Zhang, Yong K Cho, Yun Ye, Guangrong Gong, Robert J. Bache, Kâmil Uğurbil, and Arthur H. L. From1 July 1999 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 277, No. 1Twitch‐potentiation increases calcium in peripheral more than in central mitochondria of guinea‐pig ventricular myocytes7 September 2004 | The Journal of Physiology, Vol. 518, No. 2Heterogeneity of mitochondrial matrix free Ca2+: resolution of Ca2+ dynamics in individual mitochondria in situGregory R. Monteith, and Mordecai P. Blaustein1 May 1999 | American Journal of Physiology-Cell Physiology, Vol. 276, No. 5Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death8 September 2004 | The Journal of Physiology, Vol. 516, No. 1Release of Ca 2+ from the sarcoplasmic reticulum increases mitochondrial [Ca 2+ ] in rat pulmonary artery smooth muscle cells8 September 2004 | The Journal of Physiology, Vol. 516, No. 1Mitochondrial regulation of the cytosolic Ca 2+ concentration and the InsP 3 ‐sensitive Ca 2+ store in guinea‐pig colonic smooth muscle8 September 2004 | The Journal of Physiology, Vol. 516, No. 1PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDHSalvatore Pepe, Naotaka Tsuchiya, Edward G. Lakatta, and Richard G. Hansford1 January 1999 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 276, No. 1Role of Mitochondria in Calcium Regulation of Spontaneously Contracting Cardiac Muscle CellsBiophysical Journal, Vol. 75, No. 4NADH Fluorescence in Isolated Guinea-Pig and Rat Cardiomyocytes Exposed to Low or High Stimulation Rates and Effect of Metabolic Inhibition with CyanideBiochemical Pharmacology, Vol. 56, No. 2Evidence that mitochondria buffer physiological Ca 2+ loads in lizard motor nerve terminals22 September 2004 | The Journal of Physiology, Vol. 509, No. 1Model of β-cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variablesGerhard Magnus, and Joel Keizer1 April 1998 | American Journal of Physiology-Cell Physiology, Vol. 274, No. 4Reduced Ca2+ uptake by mitochondria in pyruvate dehydrogenase-deficient human diploid fibroblastsRodolfo A. Padua, Kyle T. Baron, Bhaskar Thyagarajan, Colin Campbell, and Stanley A. Thayer1 March 1998 | American Journal of Physiology-Cell Physiology, Vol. 274, No. 3Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria in intact heartsJ. Michael O’Donnell, Chris Doumen, Kathryn F. Lanoue, Lawrence T. White, Xin Yu, Nathaniel M. Alpert, and E. Douglas Lewandowski1 February 1998 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 274, No. 2A decrease of both [Ca2+]e and [H+]e produces cell damage in the perfused rat heartCell Calcium, Vol. 22, No. 6Mitochondrial Response to Heart Rate Steps in Isolated Rabbit Heart Is Slowed After Myocardial StunningCirculation Research, Vol. 81, No. 1Inhibition of mitochondrial calcium efflux by clonazepam in intact single rat cardiomyocytes and effects on NADH productionCell Calcium, Vol. 21, No. 4RESPIRATORY DEFECT AS AN EARLY EVENT IN PRESERVATION-REOXYGENATION INJURY OF ENDOTHELIAL CELLS1Transplantation, Vol. 63, No. 1Calcium in suramin-induced rat sensory neuron toxicity in vitroBrain Research, Vol. 742, No. 1-2Metabolic, catecholamine, and endurance responses to caffeine during intense exerciseM. Jackman, P. Wendling, D. Friars, and T. E. Graham1 October 1996 | Journal of Applied Physiology, Vol. 81, No. 4Intracellular free Na+ concentration increases in cultured retinal cells under oxidative stress conditionsNeuroscience Research, Vol. 25, No. 4Increase of voltage-sensitive calcium channels and calcium accumulation in skeletal muscles of streptozocin-induced diabetic ratsMetabolism, Vol. 44, No. 11Effect of Aminophylline on High-energy Phosphate Metabolism and Fatigue in the DiaphragmAnesthesiology, Vol. 83, No. 3Decoding of cytosolic calcium oscillations in the mitochondriaCell, Vol. 82, No. 3Bioenergetics in the pathogenesis, progression and treatment of cardiovascular disordersMedical Hypotheses, Vol. 44, No. 5[24] Mitochondrial cation transport systemsCaffeine and Ca2+ stimulate mitochondrial oxidative phosphorylation in saponin-skinned human skeletal muscle fibers due to activation of actomyosin ATPaseBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1188, No. 3The effect of calcium on mitochondrial contact sites: a study on isolated rat heartsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1224, No. 3Central neural mechanisms mediating excitation of sympathetic neurons by hypoxiaProgress in Neurobiology, Vol. 44, No. 2Regulation of fatty acid oxidation in the mammalian heart in health and diseaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1213, No. 3Intracellular Ca2+ transients in isolated perfused rat heart: measurement using the fluorescent indicator Fura-2AMCell Calcium, Vol. 16, No. 2Characterization of Ca2+ transport in Euglena gracilis mitochondriaBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1186, No. 1-2Ions and energy in mammalian brainProgress in Neurobiology, Vol. 43, No. 1Relationship between intracellular calcium and oxygen consumption: Effects of perfusion pressure, extracellular calcium, dobutamine, and nifedipineAmerican Heart Journal, Vol. 127, No. 2Glutamate impairs neuronal calcium extrusion while reducing sodium gradientNeuron, Vol. 12, No. 2Caffeine-induced calcium release from internal stores in cultured rat sensory neuronsNeuroscience, Vol. 57, No. 3Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchangeTrends in Pharmacological Sciences, Vol. 14, No. 11The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesisBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1142, No. 1-2Regulation of fatty acid oxidation in mammalian liverBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 1167, No. 3Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1)Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1175, No. 1Myocardial energetics during ventricular fibrillation investigated by magnetization transfer nuclear magnetic resonance spectroscopy.Circulation Research, Vol. 71, No. 5Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.Circulation Research, Vol. 71, No. 3Demonstration of ryanodine-induced metabolic effects in rat liverBiochemical Pharmacology, Vol. 44, No. 3Hexose metabolism in pancreatic isletsBiochemical Medicine and Metabolic Biology, Vol. 48, No. 1Fasting induced alterations in mitochondrial palmitoyl-coa metabolism may inhibit adipocyte pyruvate dehydrogenase activityInternational Journal of Biochemistry, Vol. 24, No. 5Oxygen and acid chemoreception in the carotid body chemoreceptorsTrends in Neurosciences, Vol. 15, No. 4The effect of alkanols on Ca2+ transport in brain mitochondriaCell Calcium, Vol. 13, No. 1Selective stimulation of in situ intermediary metabolism by free calcium in permeabilized rat adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1133, No. 1Aortic and carotid body chemoreception in prolonged hyperoxia in the catRespiration Physiology, Vol. 86, No. 2Regulation of renal ammoniagenesis in metabolic acidosisKidney International, Vol. 40, No. 5Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbateBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1095, No. 1Control of oxidative phosphorylation in mitochondria, cells and tissuesInternational Journal of Biochemistry, Vol. 23, No. 11Alcohol stimulates Na+/Ca2+ exchange in brain mitochondriaLife Sciences, Vol. 48, No. 10An hypothesis: Phosphorylation fields as the source of positional information and cell differentiation—(cAMP, ATP) as the universal morphogenetic turing coupleProgress in Biophysics and Molecular Biology, Vol. 56, No. 2Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular storesPharmacology & Therapeutics, Vol. 50, No. 2Mechanisms involved in the hormonal regulation of mitochondrial function through changes in the matrix volumeBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1018, No. 2-3The role of mitochondrial Ca2+ transport and matrix Ca2+ in signal transduction in mammalian tissuesBiochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1018, No. 2-3Ca2+ binding to citrate cycle dehydrogenasesInternational Journal of Biochemistry, Vol. 22, No. 10 More from this issue > Volume 70Issue 2April 1990Pages 391-425 Copyright & PermissionsCopyright © 1990 the American Physiological Societyhttps://doi.org/10.1152/physrev.1990.70.2.391PubMed2157230History Published online 1 April 1990 Published in print 1 April 1990 Metrics