荧光
化学
谷胱甘肽
光化学
生物物理学
组合化学
生物化学
生物
酶
量子力学
物理
作者
Ying Xia,Huihui Zhang,Xiaojiao Zhu,Min Fang,Mingdi Yang,Qiong Zhang,Xiaowu Li,Hongping Zhou,Xingyuan Yang,Yupeng Tian
标识
DOI:10.1016/j.dyepig.2018.12.024
摘要
Abstract A series of compounds (W1-W8) based on triphenylamine with -C=N- or -NH- group, were designed and studied by fluorescence emission spectra and DFT/TDDFT calculations. Probes W1-W4 were selectively leveraged to sensitively detect glutathione by two distinct reaction mechanisms, thereinto, W1-W2 featured a convenient detection for glutathione using hydrolysis and W3-W4 utilized displacement to probe glutathione possessing sensitivity and practicability. Compound W5-W8 here provided an avenue for understanding structure-property relationship. Taken considerations for toxicity and biocompatibility together, W1-W4 showed great advance for endogenously and exogenously imaging GSH in living cells.
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