阿尔戈瑙特
RNA干扰
生物
核糖核酸
基因
计算生物学
机制(生物学)
表观遗传学
基因表达
Piwi相互作用RNA
RNA沉默
基因沉默
DNA定向RNA干扰
细胞生物学
遗传学
认识论
哲学
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2018-08-02
卷期号:19 (8): 622-630
被引量:3
标识
DOI:10.2174/1389201019666180802145134
摘要
Small double-strand RNAs (dsRNAs) molecules are able to activate endogenous genes via an RNA-based promoter-targeting mechanism. Like RNA interference (RNAi), RNA activation (RNAa) is an evolutionarily conserved mechanism that is present in diverse eukaryotic organisms ranging from yeast to humans.The small activating RNAs (saRNAs) that are involved in RNAa have been successively used to activate gene expression in cultured cells. Thus, this emergent technique might allow us to develop biotechnological and therapeutic applications without the need to synthesize hazardous construct systems that harbor exogenous DNA sequences.Accordingly, this article aims to provide insights into how RNAa cellular machinery can be manipulated to activate gene expression and for more effective clinical treatments of diverse diseases.
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