清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Targeted metabolomics analysis reveals the association between maternal folic acid supplementation and fatty acids and amino acids profiles in rat pups

二十碳五烯酸 氨基酸 花生四烯酸 亚油酸 化学 新陈代谢 多不饱和脂肪酸 脂肪酸 脂肪酸代谢 亮氨酸 蛋氨酸 异亮氨酸 生物化学 亚麻酸
作者
Zhi‐Peng Liu,Rui Liu,Jing Chou,Jiaying Yu,Xiaowei Liu,Changhao Sun,Ying Li,Liyan Liu
出处
期刊:Journal of Chromatography B [Elsevier BV]
卷期号:1090: 101-109 被引量:10
标识
DOI:10.1016/j.jchromb.2018.05.013
摘要

Maternal diet during pregnancy can influence offspring's health by affecting development and metabolism. This study aimed to analyze the influence of maternal folic acid (FA) supplementation on the metabolism of rat pups using targeted metabolomics. Twenty female rats were randomly assigned to a FA supplementation (FAS group, n = 10) or control group (n = 10), which were fed AIN93G diet with 2 or 10 mg/kg FA, respectively. We then measured amino acids and their derivatives, biogenic amines, and fatty acids in the female rats and their pups by ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC/MS-MS) and gas chromatography-mass spectrometry (GC/MS-MS). In maternal rats, the significant changes of three metabolites (proline, γ-aminobutyric acid and esterified octadecatetraenoic acid, P < 0.05) were observed in FAS group. For the rat pups, FAS pups had significantly lower homocysteine and higher FA levels than control pups. The lower levels of amino acids (leucine, isoleucine, serine, proline) were obtained in FAS pups. Furthermore, there were the decreased esterified fatty acids (arachidonic acid, eicosapentaenoic acid, and docosatetraenoic acid) and free fatty acids (oleic acid, linoleic acid, γ-linolenic acid, octadecatetraenoic acid, arachidonic acid, eicosapentaenoic acid and selacholeic acid) in FAS pups. Metabolic changes in the FAS pups were characterized by changes in fatty acids and amino acids. These results suggested that FA supplementation during pregnancy influenced amino acids and fatty acids metabolism in rat pups. This study provides new insights into the regulation of amino acids and fatty acids metabolism during early life.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Qian完成签到 ,获得积分10
9秒前
34秒前
玄之又玄完成签到,获得积分10
46秒前
糯米团的完成签到 ,获得积分10
48秒前
爆米花应助ceeray23采纳,获得20
55秒前
爆米花应助彦嘉采纳,获得10
1分钟前
1分钟前
ceeray23发布了新的文献求助20
1分钟前
zpc猪猪完成签到,获得积分10
1分钟前
Jenny发布了新的文献求助50
1分钟前
香蕉觅云应助ceeray23采纳,获得20
1分钟前
hoshi完成签到 ,获得积分10
2分钟前
woxinyouyou完成签到,获得积分0
2分钟前
思源应助方俊驰采纳,获得10
2分钟前
yuyuyu完成签到 ,获得积分10
2分钟前
2分钟前
方俊驰发布了新的文献求助10
2分钟前
方俊驰完成签到,获得积分10
2分钟前
2分钟前
ceeray23发布了新的文献求助20
2分钟前
研友_8y2G0L完成签到,获得积分10
2分钟前
liwang9301完成签到,获得积分10
3分钟前
3分钟前
3分钟前
lyj完成签到 ,获得积分10
3分钟前
Xuancheng_SINH完成签到,获得积分10
3分钟前
郭俊秀完成签到 ,获得积分10
3分钟前
3分钟前
ChatGPT发布了新的文献求助10
4分钟前
披着羊皮的狼完成签到 ,获得积分10
4分钟前
隐形曼青应助科研通管家采纳,获得10
4分钟前
ceeray23发布了新的文献求助20
4分钟前
orixero应助ceeray23采纳,获得20
5分钟前
1233发布了新的文献求助10
5分钟前
ChatGPT发布了新的文献求助10
5分钟前
JG完成签到 ,获得积分10
5分钟前
jkaaa完成签到,获得积分10
5分钟前
1233完成签到,获得积分10
5分钟前
太清完成签到 ,获得积分10
5分钟前
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990550
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256532
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234