Saturated Fatty Acids, MUFAs and PUFAs Regulate Ferroptosis

Apoptosis, necroptosis, autophagy, and ferroptosis are distinct mechanisms of cell death. In this issue of Cell Chemical Biology, Magtanong et al. (2019) demonstrated that exogenous monounsaturated fatty acids (MUFAs) induce a ferroptosis-resistant cell state by suppressing the accumulation of lipid peroxides and decreasing levels of oxidizable polyunsaturated fatty acids (PUFAs).