Temperature detection by photoacoustic for nanoprobe-mediated photothermal therapy

Photothermal therapy is a tumor target therapy, which can induce temperature increase by laser in tumor tissue to eliminate cancer cells, without affecting surrounding healthy tissue. The temperature distribution in the tumor tissue directly determine the therapeutic efficacy. Therefore, real-time temperature monitoring is particularly important during photothermal therapy. However, accurate real-time temperature measurements in deep tissue still face many obstacles. This paper shows the feasibility of photoacoustic technology for real-time temperature monitoring with or without nanomaterials as photoacoustic contrast agents.