铜
催化作用
试剂
化学
过滤(数学)
级联
组合化学
甲苯
组分(热力学)
级联反应
多相催化
有机化学
色谱法
数学
物理
统计
热力学
作者
Yang Liao,Bin Huang,Xue Huang,Mingzhong Cai
标识
DOI:10.1002/slct.201900128
摘要
Abstract The heterogeneous cascade three‐component reaction of 2‐aminopyridines, aldehydes and terminal alkynes was achieved in toluene at 120 °C in the presence of 3‐(2‐aminoethylamino)propyl‐functionalized MCM‐41‐immobilized copper(I) complex [MCM‐41‐2 N‐CuCl] (5 mol%) and copper(II) complex [MCM‐41‐2N−Cu(OTf) 2 ] (5 mol%), yielding a wide variety of imidazo[1,2‐ a ]pyridines in mostly good to excellent yields. These two heterogeneous copper catalysts can be facilely prepared via a simple procedure from readily available and inexpensive reagents, and recovered by filtration and recycled up to eight times with almost consistent activity.
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