清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Parametric study on mouth–throat geometrical factors on deposition of orally inhaled aerosols

沉积(地质) 声门 气道 颗粒沉积 体积热力学 弗劳德数 曲率 流量(数学) 数学 几何学 医学 气溶胶 物理 麻醉 外科 地质学 气象学 地貌学 量子力学 沉积物
作者
Jinxiang Xi,Jiayao Eddie Yuan,Mingan Yang,Xiuhua Si,Yue Zhou,Yung‐Sung Cheng
出处
期刊:Journal of Aerosol Science [Elsevier]
卷期号:99: 94-106 被引量:59
标识
DOI:10.1016/j.jaerosci.2016.01.014
摘要

There is a growing need to select a realistic mouth–throat (MT) model to replace the USP induction port (IP) which underestimates MT deposition of inhaled particles. Even though there are many image-based MT models in literature, substantial inconsistencies exist regarding the critical geometrical factors that affect the MT deposition. The objective of this study was to systematically evaluate the relative importance of MT geometrical factors that affect the deposition of orally inhaled aerosols, which include the oral cavity volume, glottis area, airway curvature, and MT airway volume. Four existing MT models with different level of complexities were implemented. HyperWorks was used to vary the dimensions of the geometrical factors. For each factor, five variants were studied in each airway model. A well-validated fluid–particle transport model was used to simulate the airflow and particle deposition. The geometrical-factor-induced deposition variations were analyzed using ANOVA to determine the relative influence of each factor on particle deposition in the MT airway. Results showed that the realism of airway models significantly affected the MT deposition, and the USP IP underestimated the realistic model by up to 55%. The glottis area and total airway volume were found to be the two most predominant factors (both p values<0.01). Replacing the USP IP 90° elbow with curved bends significantly reduced the deposition. However, the MT airway curvature in the other three models had insignificant effects. The effect of the oral cavity volume was also found to be insignificant. Results of this study can provide guidance in developing or selecting a representative MT model to replace the conventional USP IP. A realistic glottis area should be retained in future computational and in vitro deposition studies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
英姑应助野椒搞科研采纳,获得10
10秒前
zz完成签到 ,获得积分10
28秒前
Danish完成签到,获得积分10
32秒前
zhangsan完成签到,获得积分10
41秒前
希望天下0贩的0应助zhzh0618采纳,获得10
48秒前
tranphucthinh完成签到,获得积分10
1分钟前
回首不再是少年完成签到,获得积分0
1分钟前
xjcy应助野椒搞科研采纳,获得30
1分钟前
xiaogang127完成签到 ,获得积分10
1分钟前
ni完成签到 ,获得积分10
1分钟前
菠萝谷波完成签到 ,获得积分10
1分钟前
明理问柳完成签到,获得积分10
1分钟前
所得皆所愿完成签到 ,获得积分10
1分钟前
gwbk完成签到,获得积分10
1分钟前
2分钟前
hiiiiiii发布了新的文献求助30
2分钟前
2分钟前
2分钟前
Shirley发布了新的文献求助10
2分钟前
2分钟前
Glory完成签到 ,获得积分10
2分钟前
桐桐应助hiiiiiii采纳,获得10
2分钟前
yuxin完成签到 ,获得积分10
2分钟前
Kevin发布了新的文献求助10
2分钟前
2分钟前
大熊完成签到 ,获得积分10
2分钟前
sk夏冰完成签到 ,获得积分10
3分钟前
富兰克林的薄荷糖应助Oo采纳,获得10
3分钟前
Kevin发布了新的文献求助10
3分钟前
Oo完成签到,获得积分20
3分钟前
Shirley发布了新的文献求助10
3分钟前
酷酷小子完成签到 ,获得积分10
4分钟前
川藏客完成签到 ,获得积分10
4分钟前
l玖应助Oo采纳,获得30
4分钟前
4分钟前
Sunnpy发布了新的文献求助30
4分钟前
4分钟前
Ann完成签到,获得积分10
4分钟前
4分钟前
4分钟前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162346
求助须知:如何正确求助?哪些是违规求助? 2813331
关于积分的说明 7899783
捐赠科研通 2472848
什么是DOI,文献DOI怎么找? 1316533
科研通“疑难数据库(出版商)”最低求助积分说明 631375
版权声明 602142