聚氨酯
材料科学
异氰酸酯
化学工程
多元醇
造粒
CTD公司
赋形剂
微球
聚合
复合材料
化学
色谱法
聚合物
工程类
地质学
海洋学
作者
Takatoshi Terada,Manabu Tagami,Toshiro Ohtsubo,Yasunori Iwao,Shuji Noguchi,Shigeru Itai
标识
DOI:10.1016/j.ijpharm.2016.05.061
摘要
In this report, a new solventless microencapsulation method by synthesizing polyurethane (PU) from polyol and isocyanate during an agglomeration process in a high-speed mixing apparatus was developed. Clothianidin (CTD), which is a neonicotinoid insecticide and highly effective against a wide variety of insect pests, was used as the model compound. The microencapsulated samples covered with PU (CTD microspheres) had a median diameter of <75μm and sustained-release properties. The CTD microspheres were analyzed by synchrotron X-ray computed tomography measurements. Multiple cores of CTD and other solid excipient were dispersed in PU. Although voids appeared in the CTD microspheres after CTD release, the spherical shape of the microspheres remained stable and no change in its framework was observed. The experimental release data were highly consistent with the Baker-Lonsdale model derived from drug release of spherical monolithic dispersions and consistent with the computed tomography measurements.
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