自噬
生物
细胞内
病毒复制
病毒
细胞生物学
疱疹病毒科
病毒学
限制
机制(生物学)
病毒性疾病
遗传学
细胞凋亡
机械工程
哲学
认识论
工程类
作者
Dariusz Miszczak,Joanna Cymerys
出处
期刊:Postȩpy higieny i medycyny doświadczalnej
[Index Copernicus International]
日期:2014-12-04
卷期号:68: 1406-1414
被引量:5
标识
DOI:10.5604/17322693.1130653
摘要
Viruses are a very "clever" group of pathogens and well known for disrupting multiple processes in host cells. One of them is autophagy, a conserved mechanism that relies on degradation of intracellular structures in lysosomes. Autophagy can be triggered in response to viral infections and its aim is to digest viral particles, thereby limiting virus replication and spread. Induction of autophagy during viral infections is mediated by different regulatory pathways, but the biggest participation belongs to PKR and eIF2alpha. In this review we focused on the herpesvirus interactions with autophagic machinery. The Herpesviridae family presents various strategies to manipulate autophagy induction or suppression of that process may depend on cell type and stage of infection. Research carried out in the past 10 years has demonstrated the impact of herpesviruses on autophagy not only during productive infections, but in latency infections also.
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