异羟肟酸
化学
可扩展性
组合化学
杂质
锂（药物）
盐（化学）
有机化学
立体化学
计算机科学
数据库
生物
内分泌学
作者
Zhongbo Fei,Weiyong Kong,Huaimin Wang,Jianbiao Peng,Fengchun Sun,Yueyan Yin,Joginder S. Bajwa,Xinglong Jiang
摘要
A short and scalable synthesis of chiral hydroxamic acid 1, a LpxC inhibitor, is described. This work discloses a novel diastereoselective addition of 2-nitropropane-generated lithium salt to tert-butanesulfinimine. Moreover, the impurity profiles of reactions giving oily products and practical means of purifying these products are discussed in detail.
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