T-Cell Cytokines as Predictive Markers of the Risk of Allograft Rejection

免疫抑制 医学 免疫学 移植 药效学 促炎细胞因子 免疫系统 移植排斥反应 代理终结点 药理学 药代动力学 内科学 炎症
作者
Mercé Brunet,Olga Millán López,Marcos López‐Hoyos
出处
期刊:Therapeutic Drug Monitoring [Ovid Technologies (Wolters Kluwer)]
卷期号:38 (Supplement 1): S21-S28 被引量:13
标识
DOI:10.1097/ftd.0000000000000253
摘要

Over the last decade, several biomarkers and surrogate markers have surfaced as promising predictive markers of risk of rejection in solid organ transplantation. The monitoring of these markers can help to improve graft and recipient care by personalizing immunomodulatory therapies. The complex immune system response against an implanted graft can change during long-term follow-up, and the dynamic balance between effector and regulatory T-cell populations is a crucial factor in antidonor response, risk of rejection, and immunosuppression requirements. Therefore, at any time before and after transplantation, T-effector activity, which is associated with increased production and release of proinflammatory cytokines, can be a surrogate marker of the risk of rejection and need for immunosuppression. In addition, immunosuppressive drugs may have a different effect in each individual patient. The pharmacokinetics and pharmacodynamics of these drugs show high interpatient variability, and pharmacodynamic markers, strongly associated with the specific mechanism of action, can potentially be used to measure individual susceptibility to a specific immunosuppressive agent. The monitoring of a panel of valid biomarkers can improve patient stratification and the selection of immunosuppressive drugs. After transplantation, therapy can be adjusted based on the prediction of rejection episodes (maintained alloreactivity), the prognosis of allograft damage, and the individual's response to the drugs. This review will focus on current data indicating that changes in the T-cell production of the intracellular cytokines interferon-γ and interleukin-2 could be used to predict the risk of rejection and to guide immunosuppressive therapy in transplant recipients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
nnn发布了新的文献求助10
1秒前
劲秉应助谢小盟采纳,获得30
1秒前
美丽万怨完成签到 ,获得积分10
2秒前
华仔应助美满花生采纳,获得10
5秒前
所所应助Carpe采纳,获得10
5秒前
不配.应助风与沙的边缘采纳,获得30
5秒前
无名完成签到,获得积分10
6秒前
6秒前
6秒前
7秒前
科研通AI2S应助fifteen采纳,获得10
9秒前
9秒前
10秒前
在水一方应助简单的迎彤采纳,获得10
10秒前
11秒前
11秒前
11秒前
学术菜菜发布了新的文献求助10
12秒前
xxx发布了新的文献求助10
13秒前
yyyy发布了新的文献求助10
14秒前
英俊的铭应助雪山飞鹰采纳,获得10
14秒前
14秒前
roger完成签到,获得积分10
14秒前
拉尼娜发布了新的文献求助10
15秒前
香蕉觅云应助博宇采纳,获得10
15秒前
独特翠丝完成签到,获得积分20
15秒前
小二郎应助小L采纳,获得10
16秒前
cuber完成签到 ,获得积分10
17秒前
知秋不知秋完成签到,获得积分10
17秒前
不配.应助helpme采纳,获得10
20秒前
NexusExplorer应助里新采纳,获得10
22秒前
23秒前
小楼初晴完成签到,获得积分10
23秒前
聪慧谷秋完成签到,获得积分10
23秒前
香蕉觅云应助Charon采纳,获得10
24秒前
wanci应助感性的送终采纳,获得10
25秒前
27秒前
酷炫面包完成签到 ,获得积分10
27秒前
Jasper应助崽崽采纳,获得30
28秒前
学术菜菜完成签到,获得积分10
28秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3188454
求助须知:如何正确求助?哪些是违规求助? 2837909
关于积分的说明 8017766
捐赠科研通 2500624
什么是DOI,文献DOI怎么找? 1335037
科研通“疑难数据库(出版商)”最低求助积分说明 637386
邀请新用户注册赠送积分活动 605460