碘酸钾
溴化吡啶斯替明
毒性
溴化钾
碘酸盐
吡啶斯替明
溴化物
钾
化学
医学
药理学
内科学
重症肌无力
碘
无机化学
有机化学
出处
期刊:Journal of drug metabolism & toxicology
[OMICS Publishing Group]
日期:2013-01-01
卷期号:04 (02)
被引量:1
标识
DOI:10.4172/2157-7609.1000145
摘要
Subacute toxicity of pyridostigmine bromide (PB) and potassium iodate (PI) tablets upon forty five days administration were assessed by changes in body weight, hematology, serum biochemical parameters and histopathology of rat liver and kidney. LD50 of PB was estimated to be 66.9 mg/kg. At dose of 45 mg/kg/day showed decrease in body weight and liver weight with cytoplasmic acidophilic bodies and vesicular steatosis signifying hepatocellular injury. Kidney tissue developed neutrophil polymorph infiltration with inflammatory glomerulonephritis, protein casts and glomerulosclerosis. Serum SGOT, SGPT, ALP and lipid profile were elevated. The oral LD50 of PI was found to be 944.6 mg/kg. PI at 150 mg/kg dose showed anorexia and body weight loss. Serum SGOT, ALP, cholesterol and triglyceride level were elevated at 85 and 150 mg/kg dose and focal area of tubular injury and inflammatory cell infiltration occurred only at 150 mg/kg dose in kidney. The content of PB and PI has been found stable in accelerated (40 ± 2°C/75 ± 5% RH), intermediate (30 ± 2°C/65 ± 5% RH) and long term (30 ± 2°C/65 ± 5% RH) conditions. PB 30 mg/kg/day and PI 85 mg/kg/day doses are safe for rats, which are far in excess of human exposure levels.
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