体细胞
生物
基因
突变
遗传学
DNA复制
抄写(语言学)
神经科学
语言学
哲学
作者
Michael A. Lodato,Mollie B. Woodworth,Semin Lee,Gilad D. Evrony,Bhaven K. Mehta,Amir Karger,Mi Kyung Lee,Thomas Chittenden,Alissa M. D’Gama,Xinjiang Cai,Lovelace J. Luquette,Eunjung Lee,Peter J. Park,Christopher A. Walsh
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-10-02
卷期号:350 (6256): 94-98
被引量:474
标识
DOI:10.1126/science.aab1785
摘要
Individualized neuronal mutations in the human brain The neurons of the human brain can last for decades, carrying out computational and signaling functions. Lodato et al. analyzed the DNA of individual neurons sampled from postmortem human brains and found that individual neurons acquired somatic mutations (see the Perspective by Linnarsson). The mechanism of mutation involved gene transcription rather than DNA replication. Thus, postmitotic neurons would seem to be their own worst enemy: Genes used for neuronal function are the very genes put most at risk of somatic mutation. Science , this issue p. 94 ; see also p. 37
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